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Serum Protein Electrophoresis Test (SPEP Test)

Serum Protein Electrophoresis Test (SPEP Test)

Disease group: Oncology

Offer Price: Rs. 800 Rs. 721
ICMR Approved

What is the Serum Protein Electrophoresis Test?

Serum protein electrophoresis is a laboratory test used to measure the levels of different proteins in the liquid portion of the blood, known as serum. This test helps diagnose conditions that affect the body's protein levels, such as multiple myeloma and other types of cancer, autoimmune disorders, and liver or chronic kidney diseases.

It is composed of 5 groups of proteins, namely:

  • Albumin
  • Alpha-1 globulins
  • Alpha-2 globulins
  • Beta globulins
  • Gamma globulins

Your healthcare provider will typically order the SPEP test as part of a routine checkup. If you are experiencing symptoms related to an underlying protein imbalance, the Protein Electrophoresis Test can do wonders in quick treatment. It is a fast and relatively simple test that can provide valuable information about your health status.

About the Serum Protein Electrophoresis Test

What does the SPEP test consist of, and why has your healthcare provider recommended it, especially for you? Read further along this situation to educate yourself about the serum electrophoresis test.

Why do I need a Serum Protein Electrophoresis Test?

Is the serum electrophoresis test meant for you? Most medical experts recommend undertaking the test to diagnose the following conditions:

  • Diagnosing specific medical conditions: The SPEP test can diagnose conditions such as multiple myeloma (a type of cancer affecting the bone marrow) and monoclonal gammopathy (an abnormal buildup of a protein called immunoglobulin in the blood).
  • Monitoring the course of treatment: Serum electrophoresis can monitor the effectiveness of treatment for conditions such as multiple myeloma or monoclonal gammopathy. It can also help monitor the side effects of certain medications, such as chemotherapy.
  • Assessing liver function: Protein electrophoresis can be used to evaluate the function of the liver, as certain proteins, such as albumin and globulin, are produced by the liver.
  • Finding if you have malnutrition: SPEP tests can help diagnose malnutrition by measuring the levels of proteins such as albumin, which can be low in malnourished people.
  • Evaluating your immune system function: Serum Protein Electrophoresis can be used to assess the function of the immune system by measuring the levels of immunoglobulins, proteins produced by the immune system to help fight infections.

What does the Serum Protein Electrophoresis Test measure?

The serum electrophoresis test measures the levels of 5 kinds of proteins in your body. You can gauge it via a simple blood sample drawn from the vein in your arm.

How do I prepare for the Protein Electrophoresis Test?

There is no special preparation required for the SPEP test. It is a simple blood test that requires drawing a blood sample from the vein in your arm. Before the test, be wary of the following factors:

  • Do not fast unless prescribed by your healthcare professional.
  • Drink adequate water before arriving at the diagnostic center
  • Avoid consuming alcohol or smoking.
  • If you have medications, consult your healthcare provider to determine if you can take those before checking your protein electrophoresis levels.

What sample is required for the Protein Electrophoresis Test?

The SPEP test requires a simple blood sample drawn from your veins. Your healthcare professional will be able to administer the same, after which your sample is sent to the laboratory to check your S protein electrophoresis.

What happens during a Protein Electrophoresis Test?

Are you visiting your nearest diagnostic center to get a SPEP test? If yes, your healthcare professional will take the following steps to draw the blood sample:

  • Your healthcare provider will wrap a thin pipe around your arm and cleanse the target area with rubbing alcohol.
  • The expert will check for the vein in your arm and ask you to clench your fists tightly.
  • Your healthcare provider will draw a blood sample from your vein using a syringe and collect it in a vial/test tube, removing the injection from your skin.
  • They will seal the target area with a bandage to avoid bleeding and send your blood sample to the laboratory for testing. 

Usually, the SPEP blood test results will be available to you on the same day.

What are the risks involved in a Protein Electrophoresis Test?

Since the SPEP test requires a sample of your blood drawn from the veins, there are no risks associated with this test. You might experience pain or bruise at the site, which is supposed to subside on the same day.

Finding a Serum Protein Electrophoresis Test

Should you call for a SPEP test at home or get it done at your nearest clinic? Read more to find out what suits your comfort.

Can I take the Serum Protein Electrophoresis Test at home?

Yes, you can. You can contact your nearest diagnostic center to call a healthcare professional and get the SPEP test done from the comfort of your home. 

How much does the Serum Protein Electrophoresis Test cost?

The SPEP test price depends on the diagnostic center you choose to get it done. In most cases, if you have insurance coverage, it covers the expense of the test, else you can always purchase a new plan at affordable rates. 

Serum Protein Electrophoresis Test Results

Received your serum electrophoresis test results but still need to figure out the results? Check out this section to understand whether your SPEP test results fall under the normal range.

What do the Serum Protein Electrophoresis Test results mean?

The Protein Electrophoresis Test is supposed to help you gauge normal levels of 5 types of protein in your body. If your results show a lower or higher range, consult your healthcare professional to understand the best course of treatment.

What is the SPEP normal range?

You can follow the chart below to understand whether your test results fall under the normal levels of electrophoresis.


3.8-5 gm/dL

Alpha-1 Globulin

0.1-0.3 gm/dL

Alpha-2 Globulin

0.6-1.0 gm/dL

Beta Globulin

0.7-1.4 gm/dL

Gamma Globulin

0.7-1.6 gm/dL

What medical conditions can cause a high SPEP level?

The following medical conditions can cause higher than normal serum electrophoresis levels in your body:

  • Dehydration
  • Kidney or liver disease leading to inflammation
  • Anemia
  • Multiple myeloma
  • High cholesterol
  • Rheumatoid arthritis
  • Infection
  • Liver cirrhosis
  • Lymphoma

What medical conditions can cause a low SPEP level?

The following medical conditions can cause lower-than-normal serum electrophoresis levels in your body:

  • Poor nutrition
  • Kidney or Liver disease
  • Liver cirrhosis
  • Immune disorders and deficiencies

Why Choose HealthcareOnTime?

HealthcareOnTime has a PAN-India presence. Our trained medical professionals visit your home at your convenience to take your blood sample for the SPEP test and can also assist you with booking an appointment at your nearest diagnostic center. Our services are available 24x7, and medical packages are available at the most affordable rates.

Get your SPEP levels checked today under the supervision of experienced and well-trained staff. Book your test today on call or visit our website for further assistance. 

Exclusive Service and Reporting managed by our Partner Diagnostic Centre:

Thyrocare Technologies Limited - India's first and most advanced Totally Automated NABL/ICMR/CAP/ISO certified Laboratory providing accurate reports with top-rated quality service since 1995. Book your test right away because we have kept the Serum Protein Electrophoresis Test price very reasonable for all of our clients.

Book Serum Protein Electrophoresis Test (SPEP Test)

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Need help? Call 092201 45540 [9-8pm]

Test of value less than Rs.299 will cost Rs 200 extra towards collection charges

FAQs around Serum Protein Electrophoresis Test (SPEP Test)

If you have a high Protein Electrophoresis Test result, it indicates dehydration and kidney or liver diseases. All these medical conditions lead to inflammation, anemia, multiple myeloma, high cholesterol, rheumatoid arthritis, infection, liver cirrhosis, or lymphoma.

A high level of serum protein can lead to multiple medical conditions. It's prevalent in men and women and should get diagnosed without delay.

You can get your SPEP test results on the same day, i.e., within 24 hours of giving the blood sample.

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