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Serum Protein Electrophoresis Test (SPEP Test)

  • Sample Type : Blood
  • Parameters : 1
  • Report Time : 24/48 Hrs
  • Home Collection: Yes
  • Fasting : Not Required
  • Age Group: All
OFFER PRICE:  ₹777 ₹1000 30% off


Serum Protein Electrophoresis Test (SPEP Test)
18+ booked in last 3 days

Serum protein electrophoresis is a laboratory test used to measure the levels of different proteins in the liquid portion of the blood, known as serum. This test helps diagnose conditions that affect the body's protein levels, such as multiple myeloma and other types of cancer, autoimmune disorders, and liver or chronic kidney diseases.

It is composed of 5 groups of proteins, namely:

  • Albumin
  • Alpha-1 globulins
  • Alpha-2 globulins
  • Beta globulins
  • Gamma globulins

What does the SPEP test consist of, and why has your healthcare provider recommended it, especially for you? Read further along this situation to educate yourself about the serum electrophoresis test.

Why Do I Need Immunofixation Electrophoresis?

Is the serum electrophoresis test meant for you? Most medical experts recommend undertaking the test to diagnose the following conditions:

  • Diagnosing specific medical conditions: The SPEP test can diagnose conditions such as multiple myeloma (a type of cancer affecting the bone marrow) and monoclonal gammopathy (an abnormal buildup of a protein called immunoglobulin in the blood).
  • Monitoring the course of treatment: Serum electrophoresis can monitor the effectiveness of treatment for conditions such as multiple myeloma or monoclonal gammopathy. It can also help monitor the side effects of certain medications, such as chemotherapy.
  • Assessing liver function: Protein electrophoresis can be used to evaluate the function of the liver, as certain proteins, such as albumin and globulin, are produced by the liver.
  • Finding if you have malnutrition: SPEP tests can help diagnose malnutrition by measuring the levels of proteins such as albumin, which can be low in malnourished people.
  • Evaluating your immune system function: Serum Protein Electrophoresis can be used to assess the function of the immune system by measuring the levels of immunoglobulins, proteins produced by the immune system to help fight infections.

How To Prepare For SPEP Blood Test?

There is no special preparation required for the SPEP test. It is a simple Blood Test that requires drawing a blood sample from the vein in your arm. Before the test, be wary of the following factors:

  • Do not fast unless prescribed by your healthcare professional.
  • Drink adequate water before arriving at the diagnostic center
  • Avoid consuming alcohol or smoking.
  • If you have medications, consult your healthcare provider to determine if you can take those before checking your protein electrophoresis levels.

What Happens During Immunofixation Electrophoresis Testing?

Are you visiting your nearest diagnostic center to get a SPEP test? If yes, your healthcare professional will take the following steps to draw the blood sample:

  • Your healthcare provider will wrap a thin pipe around your arm and cleanse the target area with rubbing alcohol.
  • The expert will check for the vein in your arm and ask you to clench your fists tightly.
  • Your healthcare provider will draw a blood sample from your vein using a syringe and collect it in a vial/test tube, removing the injection from your skin.
  • They will seal the target area with a bandage to avoid bleeding and send your blood sample to the laboratory for testing. 

Should you call for a SPEP test at home or get it done at your nearest clinic? Read more to find out what suits your comfort.

Can I Take  SPEP Test At Home?

Yes, you can. You can contact your nearest diagnostic center to call a healthcare professional and get the SPEP test done from the comfort of your home. 

How Much Does Serum Protein Electrophoresis Test Cost?

The SPEP test price depends on the diagnostic center you choose to get it done. In most cases, if you have insurance coverage, it covers the expense of the test, else you can always purchase a new plan at affordable rates. 

Received your serum electrophoresis test results but still need to figure out the results? Check out this section to understand whether your SPEP test results fall under the normal range.

What Do SPEP Blood Test Results Mean?

The Protein Electrophoresis Test is supposed to help you gauge normal levels of 5 types of protein in your body. If your results show a lower or higher range, consult your healthcare professional to understand the best course of treatment.

What Is  SPEP Normal Range?

You can follow the chart below to understand whether your test results fall under the normal levels of electrophoresis.


3.8-5 gm/dL

Alpha-1 Globulin

0.1-0.3 gm/dL

Alpha-2 Globulin

0.6-1.0 gm/dL

Beta Globulin

0.7-1.4 gm/dL

Gamma Globulin

0.7-1.6 gm/dL

What Medical Conditions Can Cause High SPEP Level?

The following medical conditions can cause higher than normal serum electrophoresis levels in your body:

  • Dehydration
  • Kidney or liver disease leading to inflammation
  • Anemia
  • Multiple myeloma
  • High cholesterol
  • Rheumatoid arthritis
  • Infection
  • Liver cirrhosis
  • Lymphoma

What Medical Conditions Can Cause  Low SPEP Level?

The following medical conditions can cause lower-than-normal serum electrophoresis levels in your body:

  • Poor nutrition
  • Kidney or Liver disease
  • Liver cirrhosis
  • Immune disorders and deficiencies

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Ref Link:

  1. Protein electrophoresis - serum Information | Mount Sinai
  2. Serum Protein Electrophoresis - Medscape
  3. Serum Protein Electrophoresis Test - Healthline
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FAQs Around Serum Protein Electrophoresis Test (SPEP Test)

If you have a high Protein Electrophoresis Test result, it indicates dehydration and kidney or liver diseases. All these medical conditions lead to inflammation, anemia, multiple myeloma, high cholesterol, rheumatoid arthritis, infection, liver cirrhosis, or lymphoma.

A high level of serum protein can lead to multiple medical conditions. It's prevalent in men and women and should get diagnosed without delay.

You can get your SPEP test results on the same day, i.e., within 24 hours of giving the blood sample.

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  • Disclaimer: HealthcareOnTime offers extensively researched information, including laboratory testing for health screening. However, we must emphasize that this content is not intended as a substitute for professional medical advice or diagnosis. Always prioritize consulting your healthcare provider for accurate medical guidance and personalized treatment. Remember, your health is of paramount importance, and only a qualified medical professional can make precise determinations regarding your well-being. Protection Status Protection Status Protection Status