Do you know there is a test for inflammation? The CRP test is used for inflammation. Inflammation is the response made by our body when there is tissue injury or infections by bacteria, fungi, viruses, and parasites.
Let us know in detail the following points to clearly understand what the CRP test is and why we need it.
CRP test is a blood test used to check the presence of C-reactive protein in the serum that forms as a response to inflammation in the body.
C-reactive protein or CRP is a pentameric protein made by the liver in response to inflammation. Inflammation helps save our body from infections by microorganisms. Whenever there is injury or disturbance in our body inflammation happens. As a result of inflammation, there is fever, swelling, and pain.
Apart from the liver, CRP is also released from endothelial cells, adipose tissue, and muscle cells.
Whenever there is inflammation, infection or trauma activates the inflammatory cells like neutrophils which in turn activates caspase-1 that converts Pro IL-1β to IL-1β. IL-1β stimulates the release of cytokine IL-6 that activates the CRP gene in hepatocytes. CRP gene is also activated by IL-1 and TNF- α. Once the CRP gene is activated, it starts forming C-reactive proteins that are nCRP. nCRP then forms a complex with the endoplasmic reticulum. When there is inflammation then nCRP gets detached from the complex and released into the bloodstream.
Now, you may be curious to know what happens after CRP is released into the bloodstream. Let me explain in detail because then you will understand the purpose of the CRP test.
After the release of CRP from hepatic cells, CRP decreases the expression of the eNOS (endothelial nitric oxide synthase) enzyme resulting in a decrease in nitric oxide production(NO) and an increase in ROS production. Also, increased levels of CRP in the serum increase the ET-1 receptors. All these combined result in endothelial dysfunction. Endothelial dysfunction results in various vascular diseases like coronary artery disease. Increased levels of CRP result in opsonization that results in uptake of ox LDL by macrophages. When the macrophages take up ox LDL it converts into foam cells. Foam cells result in atherosclerosis.
After the macrophages get activated they trigger and activate the complement system that helps phagocytosis of microorganisms and dead cells by the macrophages.
We have seen above that inflammation causes the levels of C-reactive protein to increase in the body. C-reactive proteins can also be increased due to
The CRP test normal range in the serum is less than 10mg/L. But if the test result comes out to be more than or equal to 10mg/L then you need attention.
We can see that the CRP test acts as a biomarker indicating that there is some sort of disturbance happening in our body that needs immediate medical treatment. For example- if a person has cancer then it can trigger inflammation that leads to swelling, pain, and fever. Inflammation causes CRP levels to increase. Hence, CRP tells the doctor the risk of inflammation and what steps need to be followed after the CRP test.
If high levels of CRP are not treated properly then it can lead to coronary artery disease and lead the risk of heart attack and stroke.
CRP test is a simple blood test that can be done at the hospital, diagnostic centre, or at home.
After the blood is collected then the sample is tested at the laboratory.
In the laboratory, the sample is mixed with latex reagent. After mixing them if agglutination of the latex particles occurs then there is CRP present significantly in the serum.
There is no associated risk with a CRP test but you might feel dizzy. But you must look for the below complication:
The C-reactive protein test price in India is Rs. 400. The CRP blood cost depends on location and the diagnostic center you choose.
There are endless options from where you can get the CRP test done. But if you trust my opinion then you can opt for HealthcareOnTime. At HealthcareOnTime the CRP blood test price is affordable with quality service.
Healthcare OnTime is a leading diagnostic center in India with NABL accreditation. The tests are carried out in CAP-accredited labs.
The CRP test price at HealthcareOnTime is only Rs 400. So, we can see that the CRP test cost is very cheap. Moreover, the test is done by well-qualified healthcare professionals and other expert staff.
Also, they offer a variety of testing options, including 24/7 online and phone booking, and we provide reliable and accurate results. Their services are affordable and accessible, making them the perfect choice for anyone in need of CRP blood Test.
If you find it beneficial then share it with your close ones so that they also get benefits. If you have any queries, then you can call them or visit their Facebook page. Their team will be glad to solve your queries.
There is no need to fast for a CRP test.
CRP levels can be reduced by following an active lifestyle like doing regular exercise, a balanced diet, and no Smoking, alcohol, and drugs.
The following symptoms indicate high CRP levels in the body:
CRP test is not a specific test and CRP increases in the blood due to any kind of inflammation, injury, or tissue damage. But hs-CRP is a specific test for the heart. hsCRP is increased when the inner lining of coronary arteries is damaged.