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SHBG Testing (Sex Hormone Binding Globulin) and its Function

Sex hormone-binding globulin (SHBG) is a protein produced by the liver that plays a crucial role in the regulation of sex hormones, particularly testosterone and estrogen. SHBG testing measures the levels of this protein in the blood and provides valuable information about hormone balance and certain medical conditions.

Conditions that may require SHBG Testing (Sex Hormone Binding Globulin)

SHBG testing (Sex Hormone Binding Globulin) may be recommended in several medical conditions or situations where assessing hormone balance and function is important. Here are some conditions that may require SHBG testing:

Hormone Imbalances: SHBG testing can be useful in evaluating hormone imbalances, particularly in cases of suspected androgen excess or deficiency. Low SHBG levels may contribute to symptoms such as hirsutism (excessive hair growth), acne, and irregular menstrual cycles. High SHBG levels, on the other hand, may be associated with low free testosterone levels and symptoms of androgen deficiency.
Polycystic Ovary Syndrome (PCOS): PCOS is a common hormonal disorder in women that can cause irregular periods, ovarian cysts, and excessive hair growth. SHBG levels may be decreased in PCOS, contributing to increased levels of free androgens such as testosterone. SHBG testing can help assess the severity of androgen excess in PCOS.
Liver Disease: Liver disease, such as cirrhosis or hepatitis, can affect SHBG production and metabolism. In conditions where liver function is compromised, SHBG levels may be reduced. SHBG testing can aid in evaluating liver function and its impact on hormone metabolism.
Hyperthyroidism: Hyperthyroidism, a condition characterized by an overactive thyroid gland, can affect SHBG levels. In this condition, SHBG levels may be decreased, leading to higher levels of free testosterone. SHBG testing can be useful in assessing the hormonal changes associated with hyperthyroidism.
Metabolic Syndrome and Insulin Resistance: Metabolic syndrome, a cluster of conditions including obesity, high blood pressure, high blood sugar, and abnormal cholesterol levels, may be associated with lower SHBG levels. Insulin resistance, a key feature of metabolic syndrome, can also lead to decreased SHBG production. SHBG testing can help evaluate the metabolic and hormonal aspects of these conditions.

SHBG Testing (Sex Hormone Binding Globulin) Procedure

The SHBG Testing (Sex Hormone Binding Globulin) is a simple blood test that can be performed in a laboratory. Before the test, the patient may be asked to avoid certain medications that may affect the results. During the test, a healthcare professional will use a needle to draw blood from a vein in the patient's arm. The blood sample will then be sent to our laboratory for analysis.

Interpreting SHBG Testing (Sex Hormone Binding Globulin) Results

Normal Range: The normal range for SHBG levels can vary depending on the laboratory and the specific assay used. Reference ranges typically consider factors such as age, sex, and other individual characteristics. The laboratory report will indicate whether your SHBG levels fall within the normal range or if they are higher or lower.
Low SHBG Levels: Low levels of SHBG may indicate conditions such as polycystic ovary syndrome (PCOS), liver disease, hyperthyroidism, obesity, and insulin resistance. Low SHBG levels can result in higher levels of free testosterone and may contribute to symptoms such as hirsutism (excessive hair growth), acne, menstrual irregularities, and androgen excess.
High SHBG Levels: Elevated levels of SHBG are less common but can be associated with certain conditions. High SHBG levels may be seen in liver disease, hypothyroidism, and estrogen excess. High SHBG levels can lead to lower levels of free testosterone, which may contribute to symptoms of androgen deficiency.

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